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Senior Scientist, Sequencing Assays
Company | Resilience |
Address | , San Diego, Ca |
Employment type | FULL_TIME |
Salary | $135,000 - $168,750 a year |
Expires | 2023-07-20 |
Posted at | 10 months ago |
Resilience is seeking a talented Senior Scientist to develop next-generation sequencing (NGS) platforms and analytics for a broad portfolio of R&D programs. In this role, you will be responsible for developing and executing cutting-edge genomics assays to expand Resilience R&D’s novel biotherapeutics and biomanufacturing processes. The ideal candidate will have a proven track record of implementing new experimental and analytical approaches with a multidisciplinary team of scientists and engineers. This role requires excellent technical skills, communication, and creativity, backed by a high level of velocity and rigor.
Job Responsibilities
- Design, execute, and interpret data from sophisticated experiments and clearly communicate key findings to colleagues within Resilience R&D
- Attend and present scientific data to colleagues at internal and external meetings
- Contribute to the delivery of project goals by participating in Agile activities, including scrum team meetings, ideation, and cross-functional interactive sessions
- Drive innovation through technical development of novel sequencing-based platforms and analytics, including whole genome sequencing (WGS), whole exome sequencing (WES), epigenome, transcriptome, single-cell RNA and DNA sequencing (scRNA, scDNA)
- Contribute to experimental plans and technical roadmaps to develop and mature both existing and new assay platforms and techniques
- Identify and advise on novel bioinformatic methods and machine learning approaches to extract meaningful insights from complex data analyses
Required Qualifications
- Mastery and consistent practice of good laboratory techniques and scientific experimental design
- Significant experience with essential molecular biology concepts and methods such as PCR, purification, gel electrophoresis
- Significant experience creating figures, data visualizations, written protocols and/or presentations that clearly distill complex scientific information and roadmaps for a broad audience.
- Demonstrated track record of independent scientific problem solving using systematic, data-driven experimental design and execution
- Significant previous experience in genomics, transcriptomics, and/or proteomics, including secondary analysis pipelines
- Significant previous experience in life sciences development in an industry context
- Subject matter expertise in NGS and/or single cell sequencing assay design and execution, including sample and library preparation for complex sequencing programs enabling high-throughput, data-driven laboratory operations
- Demonstrated experience collaborating with colleagues and partners across a range of technical backgrounds and levels of expertise
The required level of technical and professional proficiency is generally gained through 8 or more years of relevant experience in industry and/or academic research and development labs.
Preferred Qualifications
- Experience with current and next-generation genome engineering and sequencing technologies, including high dimensional, multimodal and/or multiomic cell characterization methods
- Experience with current and next-generation automation systems, bioinformatics, and/or machine learning as related to biology
- Experience in interfacing with laboratory automation (e.g., automated liquid handlers) and data analysis software
- Experience with novel genome editing nucleases and editing characterization methods (e.g. off-target analyses)
- Experience designing, performing, and/or analyzing data from cell therapy QC assays (incoming patient QC, inline viability, potency and release assays)
- PhD in molecular biology, cell biology, or a related field
- Familiarity with systems used in biomanufacturing and Good Manufacturing Practice (GMP) methodologies
- Direct experience with pre-clinical R&D and IND filing for a cell or gene therapy product or technology
Other Ideal Personal Characteristics
- Intellectually curious with an open, inquisitive mind regarding the future of medicine and biomanufacturing
- Embodies the Resilience phenotypes of grit, rigor, service, EQ+IQ, builder mentality, velocity, and ownership
- Highly organized, self-motivated, and enthusiastic about taking a hands-on approach to collaborative scientific discovery efforts in a fast-paced environment
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