Scientist, Upstream Development Jobs

We are a dedicated group of scientists, physicians, and businesspeople working together toward one goal: to discover and develop therapies that can unleash the power of the body’s immune system to treat and potentially cure cancer. We are passionate about the work we do every day at Agenus to deliver on the promise of immuno-oncology. If you’re looking for an inspired environment, passionate colleagues, and a culture that nurtures learning, innovation and team success, we invite you to join us.

In The Role You Will

• Design, investigate, and execute experiments to explore all aspects of media, feeds, and cell culture optimization and product recovery from process streams.
• Lead efforts in improving current cell culture process, e.g. literature searches, vendor interactions, etc.
• Author technical developmental reports.
• Involve in technology transfer of clinical and commercial production processes to CMOs.
• Participate in writing CMC sections for regulatory submissions including IND/IMPD and BLA/MAA.
• Mentor and share expertise with research associates.
• Develop scalable cell culture processes for production of monoclonal and bispecific antibodies and fusion/trap proteins using mammalian expression systems.
• Collaborate with other functional areas, including cell line development, downstream development, analytical and formulation development and manufacturing groups.

Qualifications: About You

• Ph.D. in Biochemical Engineering/Chemical Engineering or related field with 2 years relevant experience or equivalent combination of education and experience; or BS/MS in Biochemical Engineering/Chemical Engineering or related field with 5+ years of relevant experience; or equivalent combination of education and experience.
• Require some flexibility in work schedule, occasional weekend or off-shift hours to troubleshoot and/or monitor cell culture processes.
• Experience in scale up and transfer of upstream cell culture process from small-scale to large scale bioreactors.
• Knowledge of bioreactor hardware and controllers in intermediate-to- commercial scale (1L-2000L).
• Experience in leading, engaging, and motivating others within team environments.
• Knowledge of cGMPs and process validation requirements desired.
• Experience and in-depth knowledge of state-of-the-art principles and theories in media optimization and nutrients role in fed batch fermentation.
• Knowledge of statistical analysis software (JMP).
• Development of scalable mammalian cell culture process, from small- (ambr, 1L) to intermediate- and large- scale (e.g. 1000L/2000L) bioreactors.

Agenus is Delighted to Provide you With a Comprehensive Benefits Plan, Including Some of the Following:

• Education Assistance Program
• 401k match and Financial Planning tools
• Catered Lunch
• Care.com Memberships
• Employee Stock Purchase Plans
• Free Parking
• Flexible Vacation Plan-In a time when we move at the speed of light, what matters most is what we achieve, not how many hours we clock or accrue. We want people to take breaks when they need them most and own their time. Our philosophy at Agenus is that freedom to take this time will lead to clarity, creativity and innovation through rested and refreshed eyes. With our Flexible Vacation Plan, Agenus will not limit the amount of vacation you can take. It will allow you to take the vacation time as you need, while fulfilling your job responsibilities and making meaningful contributions to our mission
• Employee Assistance Program
• Highly competitive and inclusive medical, dental and vision coverage options
• Flexible Spending Accounts for medical expenses and dependent care expenses

Our core values

The way we work sets Agenus apart.

We put the patient first

We aspire to change the world, improving the experience and options available for every single cancer patient. The answers are out there, and patients are waiting.

We are bold, and we are one

We believe that the only way to deliver on our goals is to aim high and work as one global team. We look for opportunities to challenge, collaborate with, and support one another. We aim to break conventional standards and perform at extraordinary levels.

We work with integrity, respect and honesty

These three building blocks serve as pillars for how we behave, operate, and execute our mission.

We are a culture of ownership and accountability

We hold ourselves accountable not only for exceptional results, but how we get our results.

We are obsessively curious and deeply committed to learning

We live in a fast-paced environment that requires us to learn at or above the speed of change. We believe that curiosity fuels the desire to create, and learning provides the tools to progress.

We perform at our best every day

Every day counts. We confront insurmountable obstacles, problems and choices with intellect, perseverance and hard work.